Although our favored interpretation is that BicD plays a role in dynein recruitment, past work [21], [22] suggested that in ovaries of BicD-mutant mothers, the microtubule cytoskeleton can be impaired, resulting in improper transport of components into the developing embryos.
An attractive explanation for these observations is that the excess of p24α3 had affected the supply of the machinery cargo that is required for a correct microenvironment in the early secretory pathway with the consequence of an improper transport and accumulation of POMC, and an abnormal structural organization of the Golgi apparatus in the p24α3-transgenic cells.
Second, the introduction of an aberrant stretch of amino acids into the protein might cause improper intracellular transport and secretion [13].
A subsequent detailed study using CHO and COS-7 cells revealed that p.G133Vfs*15 leptin indeed exhibits an improper intracellular transport, aggregates and accumulates in the ER, and subsequently undergoes degradation by the proteasome [14].
Improper sample collection, transport, or storage can lead to inaccurate information concerning the cow or a herd problem.
Absence of growth on minimal media lacking uracil indicates insufficient cytosolic Ura3p levels, which may result from improper protein synthesis or transport.
Of importance to clinical laboratories and epidemiologic investigations alike, the authors make an essential point that up to 75% of errors in the testing process can be attributed to improper sample collection and transport of specimens, areas that often get less attention than assay quality control.
The mitochondrial protein-folding environment can be perturbed by any changes in the organelle structure, excess production of free radicals, and/or improper function of the electron transport chain.
Other possible explanations for the persons with fever and hemorrhage who had no laboratory evidence of RVFV infection include an overly sensitive case definition; improper collection, labeling, handling, and transport of samples; other pathogens or toxins; and complications of malnutrition.
called Johnson's conviction "improper and unfair," claiming that Johnson was "transporting his white girlfriend across state lines".
