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Thus, these results demonstrate that Chk1 haploinsufficiency may result in improper CAR formation, presumably leading to unsuccessful enculeation during erythropoiesis.
Our results indicate that improper CAR formation in Chk1+/− erythroid cells during late stages of erythropoiesis, provides one of the explanations for unsuccessful enucleation.
Defects in any of these steps, caused by mutations, may result in improper filament formation leading to pathological conditions.
Thus, we postulate that increased inflammation might lead to improper bile formation and thus blockage of the IHBD.
The reduced blood volume specifically beyond the heart could be due to diminished hematopoiesis, improper vessel formation or altered heart function.
Reduced biosurfactant production, as opposed to improper flagella formation, is responsible for reduced swarming in an AHL-deficient mutant of Serratia liquefaciens [ 50].
Mutations at outer positions may cause improper filament formation through disturbed interaction with other myosin dimers and thereby perturb thick filament assembly.
The Indians were flagged for an improper formation, and Texas recovered the second onside kick and ran out the clock.
Congenital scoliosis, as a result of improper formation and/or segmentation, is the most frequent congenital deformity of the spine [29].
White finds this new coinage "intolerable both as being unlovely in itself and improper in its formation".
A dominant negative effect was strongly suggested to be due to improper coiled-coil formation of the SM myosin rod [24].
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