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Rarer still are the cases of congenital glaucoma, a defect that results in improper development of the drainage system before birth.
Such a strategy is unlikely, however, to come without costs, since the eyes carry important interpersonal and deictic information during social interaction and communication, and eye-avoidance may result in cascading effects leading to improper development of the social brain.
Improper development of the corpus callosum may manifest itself in infancy by feeding problems, delays in acquiring proper posture and the ability to walk, and impairments in hand-eye coordination, speech, and visual and auditory memory.
Since we observed that intact lungs of Creb1−/− fetal mice were paler than wildtype controls (Fig. 1I), and also that Creb1 and pCreb1 expression were often seen in pulmonary endothelial cells (data not shown), we reasoned that loss of Creb1 may impair pulmonary circulation via improper development of the lung vasculature.
Of all the phenotypes associated with Ccnd1−/− mice, the most penetrant and dramatic is improper development of the retina.
Primary congenital glaucoma (PCG) is present at birth and is characterized by improper development of the eye's aqueous outflow system.
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Nail-Patella is an extremely rare inherited disorder that can result in improper development of fingernails or toenails, and absence or underdevelopment of the knee caps, among other symptoms.
The National Physical Plan has shown that in the past decade, the urban network of Gorgon, like the rest of the country, is population absorbent and vulnerable to improper development of urban spaces (Mirali-Katouli, 2002).
This increase in the proportion of misexpressed genes may result from two non-mutually exclusive mechanisms: (1) improper regulation of genes occurring early in development may lead to improper development of particular tissues creating allometric differences in mRNA abundance relative to the parental species.
Second, male embryonic lethality may be due to improper development of extraembryonic derived tissue, potentially resulting in placental failure or incomplete chorioallantoic fusion.
When PDS is defective, however, it leads to Pendred syndrome, a rare disease that produces deafness at birth due to improper fetal development of the inner ear and accounts for 7%to10%0% of all congenital deafness.
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