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Using a log-linear method previously designed to evaluate maternal genotype and/or parent-of-origin effects in case-parent trios [19], evidence for imprinting given mother's and child's genotypes was obtained at ABCA4 rs952499 (P = 0.033) and COL2A1 rs2070739 (P = 0.05) in the NCCCTS trios.
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Klein featured Davis in his "Unsigned Hype" column before signing him to the imprint, giving Davis his first real break.
The formation of chromatin loops and hubs, compartmentalization of coregulated loci, and changes to chromatin condensation are known to participate in the process by which imprinting signals give rise to parent-of-origin differences in gene expression between alleles (Reik et al. 2004; Li et al. 2008; Terranova et al. 2008; Redrup et al. 2009; Sandhu et al. 2009).
According to [ 18, 19], the additive variance under imprinting is given by (2) if a 1 1 sex ratio is assumed.
Two of the imprints were given a benign diagnosis; both turned out to be invasive lobular carcinoma.
Compared to genome-wide data, human and mouse ortholog pairs of maternally expressed genes are less conserved in terms of cDNA identity (p < 0.05) and the encoded proteins show a trend towards reduced identity (p < 0.06; Table 1, data for individual imprinted genes are given in additional file 1).
Genomic imprinting can give rise to markedly different levels of clinical penetrance depending upon the parental origin of the disease allele.
More explorations on the development of imprinting models are given in Cui and others [ 12, 17].
They've all made a lasting imprint while giving me a better sense of her own history, of her style.
I loved its imperfections, its impractically large size, and all the dents and imprints that gave such a kitschy item a feeling of history.
And so it is that Fair Warning, the Rails' debut album, will be released on the same imprint that gave us classics by John Martyn, Nick Drake and Fairport Convention.
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