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The manuscript is clearly written and provides important new insights into cellular F- homeostasis, as it provides solid experimental evidence that the Fluc family of fluoride channels, with their impressive selectivity for F- over Cl-, enable cells to maintain a low intercellular F- with no direct expenditure of metabolic energy.
For example, TPZ, the most advanced clinical candidate, suffers from excessive metabolic consumption as it penetrates the extravascular space, a phenomenon that diminishes its apparently impressive selectivity for hypoxic cells from 50 300 fold in vitro to the more modest range of 3 5 fold in vivo [73], [74].
The [2]catenane host system 16⋅PF6 therefore appears to display an impressive selectivity for chloride over bromide and iodide anions in DMSO, which may reflect an optimal host guest complementarity relationship between the chloride anion and the catenane's preorganised hydrogen-bond- donating binding pocket.
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The membrane fabricated from a 0.5 wt% coating solution shows an impressive CO2/N2 selectivity of 50 with the CO2 permeance of 30 GPU at 25 °C and 0.2 MPa (2 atm).
ANRIL provides a remarkable example because it involves the domestication of both new and ancient transposons with impressive site selectivity.
This assay has been further detected the WT-KRAS in the presence of KRAS single point mutants, yielding an impressive SNP selectivity factor of 2000.
When using MAO/diethylaluminumchloride as the cocatalyst, PNP/Cr III) exhibited an impressive switch in selectivity: from ethylene tetramerization to ethylene trimerization.
This system, employing MAO/DEAC as the cocatalyst, exhibited an impressive switch in selectivity of the PNP/Cr III) catalyst from ethylene tetramerization to ethylene trimerization.
In this paper, we have successfully developed integrally skinned BTDA-TDI/MDI (P84) co-polyimide hollow fibers for pervaporation dehydration of isopropanol (IPA), which have impressive flux and selectivity towards water.
The material displayed a large CO2 adsorption capacity of 4.5 mmol g−1 at 298 K and 1 atm, as well as an impressive CO2 adsorption selectivity over N2, CH4 and H2.
Compound (13c) has an IC50 of 62/170 nM for JNK1/2, excellent kinase selectivity and impressive efficacy in a rodent asthma model.
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CEO of Professional Science Editing for Scientists @ prosciediting.com