Sentence examples for impressive potency from inspiring English sources

In vitro assessment of anti-tumor activity in a panel of 12 human tumor cell lines by a monolayer assay revealed impressive potency (mean IC50<0.1.1 μM) and tumor selectivity for 6 compounds, with individual IC50 values in the low nanomolar range.

In contrast to their impressive potency in cell culture system, current FLT3 inhibitors as single agent predominantly induce transient reduction of peripheral, but not bone marrow blasts in clinical trials [4].

More interesting is the impressive potency relative to therapeutic concentrations by which panobinostat stimulated HIV-1 expression in the latently infected cell lines and primary T-cells.

Manipulation of the Zolpidem structure, notably, to structural isomers ("anagrams"), attains remarkably improved potency (5, MIC of 0.004 μM) and impressive potency against clinically relevant drug-sensitive, multi- and extensively drug-resistant Mtb strains (MIC < 0.03 μM).

60 Clonogenic assay analysis revealed impressive potency of the recombinant vector complexed with iNOS pDNA, with a viable surviving fraction only of 0.4% of control after transfection of ZR-75-1.

We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles.

Importantly, through genetic modification we were able to create EGF4KDEL 7Mut, a second generation BLT with nearly 90% less immunogenicity that showed impressive in vivo potency against a highly aggressive and difficult to treat H513 xenograft model (Frizelle et al, 2000).

The designed inhibitors retain the selectivity of our lead structure 1a towards selected members of the aminopeptidase family, combined with an impressive increase in inhibitory potency and a conserved stability.

However, we have provided new data in which Treg: effector cells were used in a ratio of 1 2, and the suppressive potency was impressive (new Figure 5A).

Among all derivatives, compound 1- biphenyl-4-yl -2-[4- 2-methoxyphenyl -piperazin-1-yl]ethanone (3c) and 1- biphenyl-4-yl -2-[4- 2-methoxyphenyl -piperazin-1-yl]ethanoneone (3k) showed impressive antipsychotic profile with lower potency for catalepsy induction.

In particular, the inhibitory effects of FN are very impressive, implying an even higher antiandrogenic potency than the model FL.