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Given the impressive efficacy of vaccination, it comes as no surprise that injectable medication is in high demand in developing countries.
Recent reports on the impressive efficacy of adoptively transferred T cells to challenge cancer in early phase clinical trials have significantly raised the profile of T cell therapy.
Compound (13c) has an IC50 of 62/170 nM for JNK1/2, excellent kinase selectivity and impressive efficacy in a rodent asthma model.
Immunotherapy with chimeric antigen receptor (CAR) T cells and bispecific T-cell engagers (BiTEs) has shown impressive efficacy against CD19+ malignancies, but translation to other tumour targets is not possible.
The mouse monoclonal antibody aurexis (also called 12-9), and the humanized version tefibazumab are therapeutic monoclonal antibodies targeting ClfA that in combination with conventional antibiotics were effective in animal models but showed less impressive efficacy in a limited Phase II clinical trial.
While the responses are very impressive, efficacy has been largely limited to a "subset of patients with a subset of cancers".
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The assumption that these agents are more active in the first-line setting without the appropriate studies is flawed, despite their impressive efficacies in other settings.
Numerous in vitro and in vivo studies indicate their impressive therapeutic efficacy.
Clinical trials in patients with advanced B cell malignancies treated with CD19-specific CAR-modified T cells (CAR-T) have shown impressive antitumor efficacy, leading to optimism that this approach will be useful for treating common solid tumors.
In summary, vemurafenib and dabrafenib have both demonstrated impressive clinical efficacy with response rates in the region of 50% in V600 BRAF mutated advanced melanoma [11,12,19].
Although targeted therapeutic agents show impressive clinical efficacy and minimized adverse effects compared with traditional treatments, the challenging drug-resistant issue has also emerged to limit their benefits to cancer patients.
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CEO of Professional Science Editing for Scientists @ prosciediting.com