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It is characterized by hyperuricemia and all of its consequences, as in gout; but in addition, patients have impressive disease of the central nervous system.
Response was evaluated in 48 with overall response rate (partial response or greater) 10.5%, clinical benefit rate (minor response or greater) 21.1% and an impressive disease control rate (stable disease or greater) of 71.9%.
These targeted therapies are producing high response rates (60%70%%) and extremely impressive disease control rates (85%95%%), leading to US Food and Drug Administration approval of their use as first-line therapies in select patients with advanced NSCLC.
Nevertheless, we observed impressive disease stabilizations in a number of patients harboring such unfavourable characteristics, and future work should focus on defining features predicting therapeutic efficacy in such patients.
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Although the response rate is not impressive, the disease-control rate achieved leads to the conclusion that this drug could represent a valid option in the management of this unfavourable subgroup of patients.
Novel treatment strategies like oncolytic virotherapy have led, in some cases, to impressive effects on disease progression in human trials, suggesting that approval of an oncolytic virus therapeutic is on the horizon.
MSCs adaptability to the exposed environment has made them an impressive source for disease treatment, though the full understanding of MSCs mechanism is still in their preliminary stages.
One part of this protection of the bicentennial generation is vaccination," he said, adding that impressive achievements in disease eradication and elimination have been made in the Americas.
Autologous cancer vaccines have recently demonstrated impressive prolongation of disease-free intervals and survival times in dogs with lymphoma.
As a result of decades-long efforts, impressive lists of disease-gene association pairs were generated [ 42, 43].
The World Health Organisation's (WHO) 2013 malaria report said that despite impressive gains against the disease, the expansion of interventions to keep mosquitoes away from human skin had slowed due to "a lack of funds to procure bed nets".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com