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Moreover, the outcome was evaluated using the clinical global impression improvement (CGI-I) scale.
Patients evaluated also the impact of antidepressant therapy in their MDE using the Patient Global Impression – Improvement (PGI-I) and a VAS for assessment of depression.
Statistically significant reductions in MADRS HAMD-17, Clinical Global Impression – Improvement (CGI-I), and CGI – Severity (CGI-S) scale scores were observed with vilazodone versus placebo, including significant differences on the MADRS and HAMD-17 at week 1.
Primary outcome measures were the independent evaluator-rated NIMH-Trichotillomania Severity Scale, a semi-structured interview often used in trichotillomania treatment trials, and a post-treatment clinical global impression improvement rating (CGI-I).
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Our primary outcome both of short-term and long-term efficacy was "response" defined by global judgement, such as "very much" or "much" improved in Clinical Global Impressions – Improvement scale if the data were available.
YBOCS, Yale Brow Obsessive-compulsive scale; MADRS, Montgomery Asberg Depression Rating scale; CGI-s, Clinical global impressions severity; CGI-I, Clinical global impressions – improvement; LSAS, Liebowitz Social Anxiety Scale; CAPS, Clinician Administered PTSD scale.
44 The indirect comparison showed a superior reduction in the mean International RLS Study Group Rating scale score, higher Clinical Global Impressions – Improvement scale response rate and significantly lower incidence of nausea, vomiting, and dizziness for pramipexole compared to ropinirole.
More subjects taking active drug were considered to be "very much improved" or "much improved" as rated by the Clinical Global Impression-Improvement (CGI-I) scale by week 24 than placebo (42% vs 14%).
Clinical response was defined as a Clinical Global Impressions-Improvement (CGI-I) score of 1 (very much improved) or 2 (much improved).
Clinical global impression-improvement.
All subjects underwent 9 weeks of Internet-delivered cognitive behaviour therapy in a randomized cross-over design and independent assessors used the Clinically Global Impression-Improvement (CGI-I) scale to determine treatment response.
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