Schemes to place coal bunkers near the outside of the ship proved impractical, but research during World War I showed that the basic idea of keeping the underwater explosion at a distance from the interior of the ship was correct.
Toxicological testing of even the most common chemical combinations is impractical, so research often focuses on efficient study designs and statistical methods that minimize the number of animals and dose groups, often only detecting departures from dose addition.
EE isn't easy to diagnose; biopsies are definitive but impractical for research, says Stephen Luby, a professor at Stanford University's Freeman Spogli Institute for International Studies.
Where electronic coding is not routine practice, or where downloading of data is impractical, a research nurse from the PCRN will visit practices and record salient data using a standardised proforma.
Despite some exceptions, such as incidences of >37 % for spontaneous pituitary tumours in male Wistar Hannover rats over one-year old [10], the unpredictable age of disease onset and frequency renders such "natural" models impractical for preclinical research.
Investigators not only expressed preference for the latter but also noted that this method was time-consuming and impractical when the research clinics are busy.
The most theoretically valid measures use implicit association or response time tasks to directly assess cue-behaviour associations, but these are impractical in uncontrolled research settings.
However, providing meaningful automatic remuneration to a large sample of GPs to undertake a questionnaire survey may render the research impractical.
Although gold standard diagnosis of gout is based upon aspiration of joint fluid for the identification of urate crystals [ 32], it is impractical for epidemiologic research.
In this respect, it may have advantages over formal quantification methods which, although possibly less subjective, are time-consuming and would probably be impractical outside a research setting.
