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One characteristic of anonymised or de-identified registers may be that it is virtually impossible to replace all PIs, aggregate all unique information and maintain the research value of the database [ 8].
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It also has staggered elections for its directors, making it impossible to replace the entire board all at once.
Soaring real estate prices make it all but impossible to replace the shelter beds, says Nancy Wackstein, executive director of the nonprofit Lenox Hill Neighborhood House, which has run the shelter under a city contract since 1996.
Nowhere is this truer than in Georgia, where farmers are finding it nearly impossible to replace the immigrant workers--not all Mexicans, to be sure--who are fleeing the state in fear of draconian new legislation.
Instead of reboots, they had spin-offs such as Star Trek: The Next Generation with all-new characters, as it seemed foolhardy and impossible to replace Shatner as Captain Kirk.
We will find them impossible to replace.
"He is almost impossible to replace".
"It is impossible to replace him".
Once lost, it's almost impossible to replace.
In reality, however, those are the kinds of losses which are almost impossible to replace.
If it is allowed to come crashing down, it will be virtually impossible to replace.
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