In addition, it is impossible to attribute observed differential expression to individual cell types.
However, owing primarily to the presence and variable intensity of the broad fluorescence band, we found it impossible to fit the observed spectral data with bands that exhibited systematic peak positions, intensities and peak widths as a function of pH and ΣS/ΣAs.
It is thus impossible to determine whether observed deviations are spatially correlated or localised at random.
In the current observational study [ 1], it is impossible to tell whether the observed higher blood pressure was a reflection of more vasoconstriction, less vasodilation (for example, sedation), avoidance of hyperventilation, or a better cardiac output.
With time-series being characterised by their internal correlation structure (auto-correlation), it is impossible to know whether the observed saliva response depends on plasma cortisol or on the previous cortisol-state within the observed saliva time-series.
But even if we can circumvent the collapse problem, the more serious difficulty of this point of view is that it appears to be impossible to understand how specific observed values q, q′, q″, … can emerge from the same Ψ.
It is impossible to reliably attribute the observed survival benefit to any specific component of optimal clinical management.
As we have a single measurement for each time point, it is impossible to determine whether the observed differences in fold changes are statistically significant.
Given the nonexhaustive panel of measured cytokines and the impossibility of relating measured cytokine levels to a net proinflammatory or anti-inflammatory balance, it is impossible to conclude whether the observed hyporeactivity leads to a proinflammatory or anti-inflammatory imbalance.
Based on our understanding of the market constraints within the German hospital sector, we assumed variable returns to scale, which may be appropriate when it is impossible to assume that all observed units are operating at an optimal scale [ 34].
