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Calculation of this parameter often causes computation problems as it does not increase asymptotically with increasingly late character divergence, and hence becomes impossible to estimate when diversification occurs very late on the tree.
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Current running times of the MCEM algorithm would render it difficult, but not impossible, to estimate the heritability when using a realistic number of genotyped SNPs.
"It is like a Band-Aid to a gunshot wound to the heart," said Mr. Holcomb, who says it is impossible to estimate how many of the birds will survive when returned to the wild.
It is impossible to estimate how wide he is because perspective grows warped and wrong when it approaches him.
It is impossible to estimate how much he weighs, because weight grows warped and wrong when it approaches him.
Especially, when the number of training patterns is limited, it is impossible to estimate p(x | c) accurately.
If it is tough to predict when sales of technology equipment will come back, it is downright impossible to estimate future profit margins of these companies.
This makes it impossible to estimate the channel, a critical component for the classical MMSE estimator.
It is impossible to estimate the exact number of portraits painted during the Tudor era, but only a fraction were made before 1558, when Elizabeth I ascended to the throne and through portraiture promoted her own image as the Virgin Queen.
Impossible to estimate.
The number of those followers is impossible to estimate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com