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Because of its complex history and tendency to borrow from other musical and cultural forms, it has been argued that "it is impossible to bind rock music to a rigidly delineated musical definition".
The idea is from intuition that binding residues are always locate on concave protein surface and the residues on convex surface are unlikely (not impossible) to bind ligands.
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In immunosensing, by contrast, it is practically impossible to remove bound antigens from antibodies without damaging the antibodies, because both antibodies and antigens are proteins in nature.
In it, Millar claimed that "to satisfy the earnest Demand of the Publick, this Work is now printing at four Presses; but the Proprietor not-withstanding finds it impossible to get them bound in Time without spoiling the Beauty of the Impression, and therefore will sell them sew'd at Half a Guinea a Sett".
In the presence of the α-helix, a narrow pantothenic acid-binding pocket is formed making it impossible for statins to bind.
Although all NiFe-hydrogenases share two characteristic motifs with altogether four cysteins at the N- and C-terminus for the binding of the NiFe active site, it is impossible to design degenerated primers that bind to the genes of all different classes of these enzymes.
Without further study it is impossible to know exactly which ligands bind CCR1L, however given the restriction of CCR1L to cattle and possibly other related species it is interesting to note that cattle have a unique CC-chemokine, regakine, which seems to synergise with CXCL8 to increase neutrophil migration but for which no receptor has currently been identified [ 38, 39].
Furthermore, since free Taxol binds the inner surface of microtubules, it would be topologically impossible for intact microtubules to bind the crystal via the previously characterized Taxol-binding site [5].
The consequences of implementation of formal rules of usage are impossible to predict, because they are bound to collide with current informal practices.
Human error is impossible to eliminate entirely and is bound to happen.
Perusing the booths of the 269 galleries exhibiting at this year's edition of Art Basel Miami Beach was effectively impossible to do nonstop; fairgoers were bound to need a coffee or Cubano refuel at one of the many cafés in the convention center at some point.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com