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Among the impossibilities so far?
We see here not the contract between civilisation and the empty world as in the second scenario, but rather the contrast between high- and low-technology, the meeting of alien cultures, the impossibility of understanding a society so far outside one's own, and the place of tribal peoples in a galaxy filled with space travellers.
Absurdly, as if conceding the impossibility of ever being Mr. Godard, Mr. Bertolucci went so far as to assert: "I am Marcello, and I make fascist films and I want to kill Godard who is a revolutionary".
Evidently, the number of size classes of protein families, N, should be finite, although intrinsic features that could determine the value of N so far have not been considered (the impossibility of an infinite genome is self-evident but one would expect a much tighter bound based, e.g., on the limited time and resources available for genome replication and expression).
If you think the Phillies are so far out of contention that the playoffs are an impossibility, well, I've got a sand-flavored ice cream sandwich to sell you.
This is due to the 1) the near impossibility of cleanly isolating both input and output variable(s), 2) the lack, so far, of longitudinal studies, and 3) the difficulty of setting up any meaningful double blind test designs.
However, studying how wind-mediated movements actually happen has been hampered so far by the lack of high resolution global wind data as well as the impossibility to track aerial movements.
The first intervention of this nature took place 8 years ago and the patients involved have suffered no relapses so far, providing proof of concept of the approach (Haissaguerre, 2002b; Knecht, 2009) However, the impossibility of creating more elaborate maps forces us to rely on experimental and theoretical modelling studies of this lethal condition.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com