Exact(1)
bDetails of fitting procedure to get the dependence σ0 is provided in the Additional file 1. cThe condition log2 vT > LVTh is a convenient way if imposing expression dependent variance filter with threshold defined by properties of the null features distribution (see eq. 11).
Similar(59)
Îjî noted that in what he took to be unproblematic cases the meaning in the mind of the one imposing the expression is identical to the meaning it has in actual speech situations.
Therefore, it is possible that the phaseolin promoter, when expressed in different systems, could be affected by elements that may impose temporal expression variations.
In the case of MAQC dataset, which has been chosen for the exact reason of it's extreme gene expression variability, imposing the restriction of expression fold change of less than 2 reduces the total number of genes considered by 31% (from 17665 to 12198).
This suggests that low level PPARγ expression stabilizes the TS cell undifferentiated state under growth conditions, while high level expression favors syncytiotrophoblast formation when differentiation conditions predominate (Figure 12); artificially imposing high level expression in the absence of differentiation conditions may suppress TS cell proliferation directly.
For example, the cytokines interleukin-21 (IL-21) and IL-2, along with intercellular interactions such as CD40 ligation, all present in the GC of the tonsil, have been shown to down-regulate the expression of Epstein-Barr virus nuclear antigen-2 (EBNand and up-regulate the expression of LMP1, thus imposing a type II expression profile similar to that observed in cHL [74], [75].
After 8 days in the neural differentiation protocol, cells in which heterogeneous Nanog expression was initially imposed showed increased expression of neural markers in comparison to cells maintained in 1 μg/ml doxycycline.
The authors try to explicitly separate the real pattern of expression from the Gaussian noise imposed onto the expression data.
The benefits of expressing BRCA1 from adenovirus are several-fold in that gene copy number and expression levels can be fully controlled without imposing possible cell selection and expression artifacts resulting from stable and transient expression from plasmids.
However when such efforts extend to echoing and mirroring the most heavy-handed restraints on freedom of thought and expression, effectively imposing a theocratic, fundamentalist rulebook on believers and non-believers alike, it is a victory not for progressive liberalism but for dogmatic oppression.
In this study we constructed a novel computational framework for circadian gene identification using deep neural networks (DNN) – a deep learning algorithm which can represent the raw form of data patterns without imposing assumptions on the expression distribution.
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