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Metastasis represents the definite cause of 90% of deaths from solid tumors and it emerges from the somatic evolution of a genetically variegated cancer-cell population under the selective pressures of an environment that imposes tight rules on cellular behavior.
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After all, California imposes tighter rules on companies than do most other American states, but its long boom suggests that greenery and growth can coexist comfortably.China and India might well come more swiftly to the negotiating table if they faced the possibility of losing their export markets.
In August, Beijing imposed tight rules on nominations for candidates wanting to stand for election.
The agency held up as examples new laws in Florida and Nevada that impose tighter rules on tracking drugs and licensing wholesalers.
Guangdong, in turn, imposed tighter rules in the mid-1990's and shut many of the smaller scrapyards.
City officials said they would also impose tighter rules on how commercial waste stations operate in order to reduce pollution, odor and traffic in affected neighborhoods.
These include requiring daily, instead of quarterly, reporting of capital (many banks used to let it drop between reports), imposing tighter rules on the concentration of loans and auditing several hundred banks.
The changes, he suggested, could tighten checks on who is granted aid and reduce the workload by imposing tighter rules on how far cases can be appealed, for example.
The EPA will issue regulations for new landfills this summer, consider whether to impose tighter rules on existing landfills and decide by the fall whether to impose new methane emissions limits on the oil and gas sector.
After several years of inaction, pressure is building in Washington to impose tighter rules on banks and finance companies that specialize in lending money to homeowners with blemished credit records.
Separately, MetLife, the insurance company, went to court on Tuesday challenging its designation as a "systemically important financial institution," a label under Dodd-Frank that allows regulators to impose tighter rules aimed at lessening risk-taking that might threaten the overall financial system.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com