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The lack of completely labeled training instances, imposes substantial challenges for MLC classification, especially in that most of the proposed relevant solutions do not deal with this problem [37].
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Such coverage variations impose substantial challenges for reliable CNV detection.
Common mental health problems impose substantial challenges to patients, carers, and health care systems.
Pervasive healthcare imposes significant challenges for supporting infrastructure.
Geological uncertainty imposes significant challenge in modeling oil reservoirs.
The standard imposes substantial constraints on the way the digital television signal is transmitted and received.
That, however, imposes substantial overheads on the processor, effectively slowing it down.
The restaurant sector imposes substantial impacts on the environment and society.
The disease imposes substantial costs on individuals, families and governments.
The management of uncomplicated childhood fevers imposes substantial costs on Kenyan households.
Nevertheless, methodologies for CNV detection using NGS lack well-defined workflows, protocols, and quality-control measures, imposing substantial computational and bioinformatic challenges [ 107].
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