It could eventually lead to a legally binding agreement with the city imposing significant changes in how the police operate.
In addition to gender, aging also imposes significant changes on nuclear receptor-mediated gene expression in hepatocytes [ 8].
In addition, new rules under Basel III will impose significant changes to the regulatory capital framework, prompting many smaller institutions to integrate stress testing into their risk management.
For dentists, this requires a philosophical switch that can impose a significant change in the way clinicians provide care and generate income[ 1, 3, 23].
Geological uncertainty imposes significant challenge in modeling oil reservoirs.
These include fundamental operational changes imposed by the less favorable thermodynamics, significant changes in the by-products, and significant changes in the nature and operation of the catalyst system which, in addition to Rh and iodine, also requires the presence of both a salt and a reducing agent.
First, we applied partitioned models in maximum likelihood (ML) and Bayesian (BYS) analyses to minimize bias from significant changes in base composition superimposed on saturated sequences without imposing onerous time penalties on phylogeny searches (Dávalos & Perkins, 2008).
In other words, these data illustrate that when imposing an arbitrary, non-standardized cutoff for diagnosis, small, clinically insignificant changes in the cutoff value can result in significant changes in prevalence, especially when operating at the steeper slopes of the distribution.
It is possible for example that organisms have evolved the ability to tolerate significant changes in the levels of mRNAs or other cellular components, and there is no evolutionary advantage to imposing extremely ranges on mRNA levels.
