In contrast to FBA-related techniques, EFM and ExPa analyses are only based on network stoichiometry and therefore allow an unbiased analysis without imposing an optimization principle.
Open research problems are at present the unconstrained optimization for, which imposes a burden of numerical integration and optimization.
This property imposes an additional, strong condition of the atom maps that is not captured by the optimization approaches outlined in the previous paragraphs.
However, for practical constellation sizing, the number of bits allocated per sub-carrier is restricted to integer values, which imposes a combinatorial structure in the loading optimization problem.
The topology optimization of microstructures is performed by using the bi-directional evolutionary structural optimization (BESO) method, which imposes a constraint on the effective thermal conductivity.
Executing parallel function calls imposes a lot of problems since lazy evaluation or other kinds of code optimization destroy the temporal behavior.
This ultimate dielectric thickness requirement imposes a number of challenges on both the fabrication process and the device characteristic optimization.
True, it imposes a (small) haircut.
Consequently it is less straightforward to impose a constraint during the optimization procedure to ensure a particular target rotation.
