Furthermore, since February 2012, the EMA has imposed the development of an education pack for patients and prescribers with regard to the safety and effectiveness of NOACs.
The extensive and routine use of the first-line antibiotics to control infections imposed the development of multiple mechanisms of microbial resistance.
However, the increasing need for dehydrated products of the highest quality, imposes the development of new criteria that, together with cost components, determine the design rules for any drying process.
In the interview, policymakers are invited to describe how research was searched for, obtained, appraised, generated (i.e. research engagement actions), and used (i.e. research use: conceptual, instrumental, tactical, and imposed) to inform the development of a discrete policy document (see Additional file 1 for the SAGE interview).
Earlier in this decade, several authors (most notably, Mark Roe) proposed "political" theories of corporate finance under which dispersed ownership was viewed as largely the result (in the U.S). of regulatory constraints imposed on the development of financial intermediaries.
A new approach, led by Princeton Professor of Architecture Guy Nordenson, rejects the strict dividing line between land and water that coastal planners historically have imposed, favoring the development of "amphibious suburbs" and landscapes that can tolerate periodic floods.
Where import restrictions are imposed, then the development of small scale production would appear more attractive.
These immune-evasive characteristics impose a serious challenge on the development of an effective CL vaccine [ 99].
The dynamic transformation of the regional plate margins caused differentiation of the intra-platform paleogeomorphology, which imposed changes in the development of sedimentary facies contemporaneous with the development of intra-platform shoals.
This has important implications for our view on how toxic Microcystis blooms develop, which may not so much be the result of zooplankton grazing in general but rather may reflect the outcome of interactions between defences and counter-defences in auto- and heterotrophs, comediated by the costs imposed by both the development of these defences and counter-defences.
