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The extensive and routine use of the first-line antibiotics to control infections imposed the development of multiple mechanisms of microbial resistance.
The challenging constrains on the design and operation of this system imposed the development of a complex Detector Control System to assure the operational stability and reliability of a so large and complex detector and trigger system.
Furthermore, since February 2012, the EMA has imposed the development of an education pack for patients and prescribers with regard to the safety and effectiveness of NOACs.
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However, the increasing need for dehydrated products of the highest quality, imposes the development of new criteria that, together with cost components, determine the design rules for any drying process.
The dynamic transformation of the regional plate margins caused differentiation of the intra-platform paleogeomorphology, which imposed changes in the development of sedimentary facies contemporaneous with the development of intra-platform shoals.
This has important implications for our view on how toxic Microcystis blooms develop, which may not so much be the result of zooplankton grazing in general but rather may reflect the outcome of interactions between defences and counter-defences in auto- and heterotrophs, comediated by the costs imposed by both the development of these defences and counter-defences.
In the interview, policymakers are invited to describe how research was searched for, obtained, appraised, generated (i.e. research engagement actions), and used (i.e. research use: conceptual, instrumental, tactical, and imposed) to inform the development of a discrete policy document (see Additional file 1 for the SAGE interview).
Energy crisis is one of the issues which have imposed many changes in the development of various technologies around the world.
Moo dwells too long on one topic and commits the error of monotonism and trying to impose his personality on the development of the party.
This imposes additional challenges for the development of reliable thermodynamic models.
The stochastic nature of the energy sources is fundamentally different from the deterministic energy sources employed by conventional systems, and it imposes formidable challenges on the development of energy harvesting sensing systems.
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