Epigenetic regulation based on histone modification is essential for numerous biological processes in eukaryotic organisms1,2.
Specifically, we focus on histone modification pathways recently identified as being common drivers for many types of human cancers.
Zia and Graham/Bryce have a pair of papers out in Science today: evolution of protein expression in primates and effects of genetic variation on histone modifications.
However, the complex regulation on histone modifications during cell cycle and undetermined functions of different histone modifications make our discussion more difficult.
These results suggest distinctive histone modification patterns in plants and provide an invaluable foundation for future studies on histone modifications in plants.
In this issue, K?í?ová et al. studied histone modification marks imposed on tobacco transgene loci during PTGS and TGS during dedifferentiation of cells in callus culture.
Regarding histone modification, although the acetylation levels of histone H4 have been shown to differ between dividing and differentiated cells in roots34, to our knowledge, there have been no reports on cell type-specific histone modification status.
Joe Davis has written a great blog post about Graham and Bryce's recent paper on genetic variation and histone modification.
Exogenous signals are initially imposed on the receptors, which then carry the signals to second messengers, and eventually the signals are led to transcription-related molecules of DNA in the nucleus, such as transcription factors, RNA polymerases or histone modification complexes.
We also analyzed the effect of high-B stress on other histone modifications, H3K9me1 and H3K4me3, which are related to closed and open chromatin, respectively27,28.
