bDetails of fitting procedure to get the dependence σ0 is provided in the Additional file 1. cThe condition log2 vT > LVTh is a convenient way if imposing expression dependent variance filter with threshold defined by properties of the null features distribution (see eq. 11).
Overexpression of rate-limiting enzymes in the endogenous heme biosynthetic pathway alleviates the stress imposed by expression of the P450 monooxygenases and increases the enzymatic activity of the final evolved P450 by an additional 2.3-fold.
After 8 days in the neural differentiation protocol, cells in which heterogeneous Nanog expression was initially imposed showed increased expression of neural markers in comparison to cells maintained in 1 μg/ml doxycycline.
Therefore, it is possible that the phaseolin promoter, when expressed in different systems, could be affected by elements that may impose temporal expression variations.
Îjî noted that in what he took to be unproblematic cases the meaning in the mind of the one imposing the expression is identical to the meaning it has in actual speech situations.
The authors try to explicitly separate the real pattern of expression from the Gaussian noise imposed onto the expression data.
However, this inhibitory effect is significantly imposed on BIM expression and marginally on Runx2 and c-Jun expression.
Our results do not contradict such models but reveal that in a rapidly developing system, the intrinsic rate of transcription of a target gene can be a major determinant of gene expression range: high affinity binding sites cannot overcome the limits imposed on gene expression range by low levels of intrinsic transcription.
We used single-cell gene expression profiling of GMPs, either wild-type or transduced with a control vector or a Ddit3-expressing lentivirus, to interrogate the transcriptional program changes imposed by enforced expression of Ddit3 and to inspect its role in remodeling of the transcriptional networks underlying lineage progression and/or identity.
In this study, we observed a common pattern in distribution of gene expression heritabilities among four HapMap populations (CHB, JPT, CEU and YRI), suggesting possibly similar levels of constraints imposed on the expression variability of the most genes in the populations, or no apparent evolutionary divergence has been detected to impact the expression regulatory mechanisms of these genes.
Burden imposed by alternative expression constructs.
