sources, what imposes constrains on usefulness of experimental data.
The RM method does not correct data to better fit a model but simply imposes constrains (physical laws) to improve the dataset intrinsic quality.
Thus, 36 known inhibitors of hIKK-2 (listed in Table S1) were docked with our hIKK-2 homology model without imposing constrains that forced poses to make specific intermolecular interactions with the target.
We note that this result has to be interpreted cautiously, because regulatory and structural functions in intergenic regions [ 30, 31] impose constrains that can bias the frequency of repeats.
The network approach is used in many context, which converge on the notion that a persons' behaviour is mainly the result of the web of relationships around him/her, as these relationships provide opportunities and impose constrains on people's behaviour (Katz et al. 2004; Wellman 1988).
Technological limitations are imposed to constrain the solution to commercial components.
The walker may avoid traveling through some areas in the environment, even if there are no explicit physical obstacles due to non-physical parameters (e.g., gender, age, personality, lifestyle, culture or social norms) imposed that constrain him from locomotion.
Existing quantitative models of bioirrigation rely primarily on chemical, rather than ecological, information and the depth-dependence of bioirrigation intensity is either imposed or constrained through a data fitting procedure.
"We used to see a huge influx of people coming [to the U.S.]." Now, he said, government has imposed a "constraining atmosphere" in which foreigners come for an education before being forced to take their brain power elsewhere.
This dependency can promote the persistence of a phylogenetic signal in the face of significant gene transfer when the transfer process reinforces host preferences imposed through constraining core functions.
