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Functional links between sites impose correlation in their entropies [ 43].
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Owing to the imposed correlation structure, the relevant predictors of the second model are noticeably correlated.
Such a view is appealing from a modeling perspective but imposes correlation dynamics that are similar to time-varying volatility.
Despite the fact that the lines differ at a large number of nucleotides and insertions/deletions, those differences impose a correlation structure across lines that is informative for a systems biology approach to quantitative models of complex phenotypes.
To ensure that such normalization did not impose false correlations, we looked for correlations in unnormalized data.
Given that varimax rotation may impose some correlations between the columns of the principal component matrix, we performed permutations on the rows of the unrotated matrix, subsequently applying component rotation and calculating a random map on each permutation in the same way as it was done for the real principal components.
Evaluation of the 28 LHHW adsorption constants was accomplished by imposing a correlation betwen the adsorption constant and the number of aromatic rings and the number of saturated carbons.
Comparison of model prediction with imposed random correlation demonstrated biologic relevance of the model and the reduction of overfitting in DF.
Interestingly, KCNJ11 and ABCC8 lie next to each other on chromosome 11, and are separated by only 5 kb: a large region of linkage disequilibrium imposes strong correlation among several variants across both genes [ 33].
This relaxed-clock model imposes a correlation of rates between ancestral and descendant branches by modeling rate change on the tree as a geometric Brownian diffusion process [ 53, 54].
This non-random structure is due to crystallographically imposed local correlations among boundaries.
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