Most importantly, however, widespread integrated public transport shifts the city's focus to the poor, and in bringing about changes for the most marginalised, has the potential to bring about a more equitable city for everyone.
There have been independent ethical reviews, three separate independent expert reviews of all the scientific evidence on the technique's safety, and most importantly a widespread public consultation which has revealed broad support.
Importantly, the widespread deregulation of many of these pathways in human cancer leads to the secondary inactivation of Hippo signaling, ultimately contributing to tumorigenesis (reviewed by Yu and Guan [42] and reviewed by Irvine [33]).
Importantly, the widespread acceptance of a simple taxonomy for describing personality – i.e., the Big Five – was instrumental in reigniting organizational psychologists' enthusiasm for studying the potential efficacy of personality testing (Mount and Barrick 1998).
Importantly, their widespread efforts will be able to collect information for a range of other chronic diseases that are also on the rise.
Importantly, although widespread collagen degradation can disrupt vessel integrity, SMCs have the capacity to cleave type I collagen in a highly localized and orchestrated manner, through plasma membrane-bound collagenase-1 (Li et al., 2000; Fera et al., 2004).
This finding resonates strongly with the initial experiments on Rest−/− mice, which displayed embryonic lethality around E11, but importantly, showed no widespread precocious expression of Rest target genes.
Importantly, it has widespread political support and existing partnerships with organizations such as Interpol, the World Customs Organization and civil society that are already active in the fight against counterfeit medicines [ 22].
In many cases, deficiency in education is the specific underlying cause of unsustainable land management practices, of the general lack of investment (both in education and physical measures to protect soil) and, as importantly, of the widespread political reluctance to adopt short - and long - term measures to preserve and enhance soil conditions.
