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Importantly, targeting a higher MAP in all patients was not without risk.
More importantly, targeting the Notch pathway may give us a way to enhance or inhibit an effector T cell response without inhibiting the memory T cell response, as memory T cells are more resistant to disruption of Notch signaling.
Importantly, targeting of cAMP pathway has been explored as a potential therapeutic option for the treatment of leukemia/lymphoma and therefore, could also be useful for the treatment of ATL [62] We identified dopamine, a neuromodulator, and its metabolites, methoxytyramine and homovanillic acid, in the studied T lymphocytes.
Importantly, targeting T cells specific for immunodominant epitopes of major allergens can alter responses to whole allergen extracts (linked suppression).
More importantly, targeting immune response in the CNS may provide some novel and effective treatments for CP-induced pain.
Importantly, targeting PIM-1 with either siRNA or SGI-1776 significantly enhanced the activity of sunitinib in RCC models.
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Importantly, targeted therapies have been developed for each of these driver genes.
Importantly, targeted mutation of the Siglec G gene dramatically expanded the B1a B cell lineages postnatally, by increasing NFκB activation.
Importantly, targeted imaging would also afford a sensitive technique for follow-up imaging to determine response to therapy and the presence of metastatic lesions.
More importantly, targeted antibiotic therapy for VAT may improve patient outcomes and become a new paradigm for prevention or early therapy for VAP.
Importantly, targeted depletion of GRP78 enhanced Bz-mediated cell death, justifying further studies to test if this chaperone might be an amenable therapeutic target in the resistant residual disease.
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