Importantly, sequential scheduling did not incur loss of efficacy; in these studies, median overall survival ranged from 22 to 30 months (Poole et al, 2000; Tognoni et al, 2000; Guppy et al, 2004).
Importantly, both radiotherapy schedule and sequence of the modalities in combined treatment may impact on the outcome.
More importantly, optimal dose-scheduling allows dose reduction in sunitinib by at least 50% while maintaining the same antitumor effect.
Importantly, dosing and scheduling may be crucial if 'normalisation' is the goal (Winkler et al, 2004; Jain, 2005).
Importantly, consecutive treatment schedules of necroptosis and apoptosis in either combination revealed remarkable additive effects not reached by repetitive apoptotic treatments alone.
Rodriguez added: "I'm just very happy that the weather came through for all of us, that I played a full game and, again, I'm just happy to be back out there and on schedule, more importantly".
Importantly, gambling has a schedule of reinforcement that shows similarities and differences from other addictions.
Importantly, the PLX3397 dosing schedule did not affect blood-brain barrier (BBB) integrity in rodents [5], thus is it unlikely that the reported V T values were biased by a compromised BBB.
Importantly, treatments and physiotherapy schedule were not changed for 3 months before entry and all during the trial.
Inevitably there will be teething problems – the designation of the ball as "the white bullet" on the English language commentary on Univision has already achieved cult status on social media – and perhaps just as importantly, all the smart scheduling in the world can't legislate for the fact that on some weeks, the best action happens elsewhere.
