Exact(5)
The ubiquitin-proteasome system interfaces with and importantly regulates the UPR.
AMPK importantly regulates cardiac vascular permeability and could control the sepsis-induced cardiomyopathy.
Canonical Wnt signaling is highly conserved and, importantly, regulates stem cell dynamics in many tissues, including the breast [ 23].
Interestingly, GSK-3 importantly regulates multiple proteins implicated in migration and is an important mediator in several of the signaling pathways involved.
Administration of exogenous GLP-1 peptide potentiates glucose-dependent insulin secretion and, importantly, regulates the hyperglycaemia observed in these patients (Holst and Seino, 2009).
Similar(55)
Importantly, regulated protein-protein interactions are often at pivotal positions within the interaction network in a signal transduction pathway (Wehr et al. [2008]).
Non-inactivated closed states are stabilized in the mutant channel, consistent with S4 importantly regulating not only activation and deactivation processes, but also those of CSI and recovery.
These results demonstrate that DCX is importantly regulated by GSK-3 in developing cortical neurons.
Interestingly, EMT is importantly regulated by GSK3 β inhibition of β-catenin and GSK3 β is negatively regulated by AKT.
Rho proteins function as molecular switches in many eukaryotic signal transduction pathways and, most importantly, regulate the actin cytoskeleton.
p27 is also importantly regulated by proteolysis, with the p27 t1/2 decreasing fivefold to eightfold with passage from G0 to S phase [ 18, 19].
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