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Importantly, old and newly synthesized proteins can be monitored simultaneously.
As shown in Fig. 5B, hESCs conferred a much-enhanced myogenic capacity on both young and, importantly, old myofiber-associated satellite cells (rapid formation of desmin+ myogenic cells, many of which formed de novo multinucleated myotubes).
Furthermore, the myogenic regenerative capacity of young and importantly, old satellite cells was significantly enhanced through forced activation of MAPK, and even young satellite cells failed to produce proliferating fusion-competent myoblasts when MAPK was experimentally inhibited (Fig 5E, F, Fig S6 of Supporting Information).
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We're at a tipping point where social care is in jeopardy, and unless the government addresses the chronic underfunding of the sector, there will be worrying consequences for the NHS and, most importantly, older and disabled people, their families and carers".
Importantly, older age, higher vascular risk scores, and lower baseline Mini-Mental State Examination scores predicted less change in working memory.
Most importantly, older adults were more likely to recover from exposure to distorted questions and respond correctly.
Importantly older veterans will comprise between 12-14% of the total number of participants assisted by SCSEP.
Importantly, older adults who sustain hip fracture are at an increased risk of future hip fracture [ 26, 27].
Importantly, older larvae of P. harmeri show a paired ventral neurite bundle with serial commissures and perikarya.
More importantly, older mice expose to lung injury are characterized by deficient autophagic response and reduced selective targeting of mitochondria for autophagy (mitophagy).
Importantly, older people are at increased risk of cognitive impairments due to age-related physiological changes, co-morbidities, and the presence of pre-existing cognitive decline [ 10].
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