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More importantly, efficacy studies also revealed that only the TAT-gelonin/T84.66-Hep TAT-gelonin/T84.66-Hep TAT-gelonin/T84.66-Hepumor growth (46%) without complex gelonin-induced syielded toxicity.
Most importantly, efficacy in longstanding treatment does not usually result in remission.
Importantly, efficacy is restricted to patients whose tumors do not harbor Kirsten rat sarcoma (KRAS) mutations, although rat sarcoma wild-type (WT) (RAS-WT) status does not guarantee response.
Importantly, efficacy is maintained in the absence of immunosuppression and overt hormonal effects to growth and development, providing insight into mechanisms of glucocorticoids in muscular dystrophy and demonstrating a successful separation of pathways into dystrophy efficacy and side effects.
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Importantly, vaccine efficacy did not wane as the influenza season progressed; the weekly cumulative vaccine efficacy from the beginning of March onward was >78% for antigenically matched A/H1N1 strains, >77% for all antigenically matched strains, and >70% for all strains, irrespective of antigenic match.
Importantly, the efficacy of compound A8 (IC50: 25 nmol/l) was similar to that of the established tubulin inhibitors (Fig. 8).
Importantly, clinical efficacy needs to be tested in large-scale trials.
Importantly, the efficacy observed here would also have been readily detectable in a Phase IIa CHMI clinical trial.
Importantly, cholinergic efficacy could be restored and preserved over extended time scales by periodically withdrawing cholinergic input.
More importantly, the efficacy of sunitinib was enhanced significantly when combined with IPA3 or IL-6 neutralizing antibody.
Importantly, vaccine efficacy should be maintained at its highest level to improve the efficiency of both RI and SIA.
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