Most importantly to date there is a lack of epidemiologic evidence from Sub-Saharan Africa – a region with multiple risk factors for adverse pregnancy outcomes and regionally highly variable rates of adolescent pregnancies [14] [16].
Importantly, spawning date also influences temporal reproductive isolation between species [ 26].
Importantly, to date, the activity of all ALK mutants tested can be abrogated by treatment with ALK small molecule TKIs.
Importantly, to date there is no accepted cell culture system for growing the tripotential and bipotential progenitors of the SVZ.
Importantly, to date, early safety studies suggest that the safety profile of anti-OX40 therapy is good.
More importantly, to date there have been no prior genome-wide evaluation studies (that are based on genome-wide binding and gene expression assays) assessing pathway databases.
Still, compared with CT-colonography, research on MR-colonography is rather limited and more importantly to date no consensus has been achieved regarding imaging aspects.
More importantly, to date there is no evidence that antidepressants for depression or anxiolytics for anxiety mitigate poorer health outcomes among women with depression or anxiety-related diagnoses [ 26- 28].
Importantly the dates relating to patient recruitment, the timing of the measurement of variables and the date of follow-up are also required.
Importantly for dating purposes, the youngest part of each RPCB should preferably be sampled.
