Sentence examples for importantly aged from inspiring English sources

Perhaps most importantly, aged patients who survive the initial insult are more likely to have a prolonged and complicated clinical recovery.

Importantly, aged VSMCs, both in vitro and in vivo, also accumulate prelamin A and activate persistent DDR, suggesting a key role for the nuclear lamina in vascular ageing.

Further characterization showed that this immune cell subpopulation was positive for endogenous S100a8 and S100a9 proteins and transcripts, and importantly, aged TgS100a8a9 hep animals exhibited a comparable enrichment of this specific immune subpopulation, supporting the existence of a constitutive signal in TgS100a8a9 hep mice, which leads to a sustained increase of these cells.

Importantly, aged humans with amnestic mild cognitive impairment also show hippocampal hyperactivity that has been localized to the CA3/dentate gyrus., Further, treating cognitively impaired rats with compounds to enhance inhibition improves performance on a spatial memory task confirming the detrimental effect of increased excitation.

Most importantly, aging (especially premature aging) has not been well recognized as the primary factors of most non-infectious chronic diseases.

Importantly, aging is the most important risk factor for late-onset AD [reviewed in (Pehar & Puglielli, 2012)].

Importantly, aging predominantly increased the incidence of small CMHs, suggesting that aging renders small cerebral vessels significantly more vulnerable to high pressure-induced rupture.

Importantly, aging, especially sedentary aging, is associated with augmented oxidative stress due in part to loss of β2-adrenergic responsiveness in women and uncoupling of BH4 (Moreau et al. 2005; Hart et al. 2011, 2012).

Importantly, aging is also associated with increased incidence of many cancers, including hematopoietic malignancies, and in this review we have discussed the many possible connections between aging and cancers.

Importantly, aging is associated with increased angiotensin II and other renin-angiotensin system components which, in turn, may contribute to increased cardiovascular remodeling and cardiovascular risk in the elderly.

Importantly, age, gender, and the presence of comorbidities like cardiovascular disease, cancer or dementia was not related with time until first antibiotic prescription.