For example, dedicated secondary sexual traits may indeed show positive allometry, but sexually selected modifications to structures with important viability-related functions may exhibit isometric or even negative allometric scaling due to conflicting sexual and viability selection.
Since ALK protein levels are not important for viability in mammals, ALK PROTACs could lead to novel therapeutics with minimal toxicity.
Iron is important for viability of T. brucei and Leishmania species [13], [37], [38], [39], [40].
Furthermore the Cds1 checkpoint kinase was also important for viability in cisplatin challenged cells.
Both Chk1 and Cds1 are important for viability in the presence of several DNA damaging agents.
Moreover, inactivation of either Yox1 or Nrm1 in a cds1Δ checkpoint mutant largely rescues the sensitivity of these cells to HU, indicating that de-repression of MBF-dependent transcription is important for viability in response to genotoxic stress.
Since the lethality observed for muscle specific reduction of SMN more closely resembles ubiquitous SMN reduction (compare Figure 3A and B), these indicate the requirement of SMN in the muscle (using how24BGAL4) is more important for viability than its requirement in the neurons.
This relationship supports the idea that gene dosage is important for viability of protein complexes.
Because cell size is important for viability, mating with a partner of the right size could be a significant advantage.
KDM1 is an essential gene in mouse [ 15] and important for viability and fertility in Drosophila [ 16].
Our present study shows that CaMms22p plays a vital role in preserving genome integrity during DNA replication and is important for viability after DNA replication-associated damage.
