An important caveat is that a delay in inevitable local transmission of a pandemic virus may not be desirable if it would defer local transmission into a season associated with higher transmissibility such as the winter in temperate regions [ 12], or if it led to importation and local transmission of antiviral resistant strains [ 17].
Together, the results of these studies suggest that CNV undergoes conformational change upon zoospore binding and that the conformational change is important for CNV transmissibility.
Residue 58 in PB1-F2 appeared to be important for the transmissibility of these viruses.
Distinguishing between these possibilities will be important in determining transmissibility of β-lactamase resistance.
A larger study is under way to address this important determinant of transmissibility [ 21, 22].
Simulation studies on HIV [ 8] and HSV-2 [ 9] have also shown the important role of transmissibility in driving the dynamics of drug resistance.
An important index of transmissibility for a communicable disease is the basic reproduction number (R0) that represents the number of secondary infections generated by a single infected case in an entirely susceptible population.
Nevertheless, the scrapie strain and, at least in in vitro experiments, the prion protein genotype of the animal that is the source of the infectious agent, are also important in determining scrapie transmissibility [9] [11].
Although reports of the epidemic in Mexico, the US and Canada has provided important information about the transmissibility of the 2009 pandemic H1N1 virus [7], [13], [14], little is known of the way viruses were transmitted in the community in the early phase before the epidemic.
In addition, since the nasal mucosa serves as the first target for large droplet settling, we believe that the HA mutations involved in modulating the pH and temperature stability, might be also important for the virus transmissibility besides the mutations regulating receptor binding specificity.
