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Nephrotoxicity, ototoxicity, and neuromuscular blockade are the most important toxic effects of aminoglycosides [ 7, 28].
EBDCs, and particularly the EBDC metabolite ethylenethiourea, have clearly defined, important toxic effects in various animal species, and there is reason to suspect they are carcinogenic in humans.
Genotoxicity is one of the most important toxic effects and its relevance is greater as we are dealing with events taking place at sublethal doses leading to long-term effects such as cancer and reproductive diseases.
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The most important toxic effect was observed in PTX + CIS groups.
For designing such test systems, it is important that toxic effects can be excluded, that multiple parameters can be addressed simultaneously and that mechanistic aspects can be included.
But even though the valency of the ions is important regarding toxic effects, none of the studies included were concerned with this and they only measured total ion concentrations.
Inhibiting an enzyme expressed by microbes in the human intestinal tract prevents an important toxic side effect of an anticancer drug.
One reason for the significant reduction in dHU in portal venous phase might be the sinusoid obstruction syndrome as an important toxic side effect of neoadjuvant treatment.
NSP4 consists of 175 amino acids, and sequences important for its toxic effects have been mapped to the carboxy-terminal half of the protein.
But there is also the possibility that kinase activity is really not that important for the toxic effects of LRRK2 mutations.
Oxidative stress has been recognized as an important mechanism underlying the toxic effects of metal oxide NPs, which has been extensively studied in vitro and in vivo[14 16].
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