Sentence examples for important target cell from inspiring English sources

Therefore, SSCs are an important target cell for restoring male fertility, particularly for cancer patients who have to undergo sterilizing cancer therapies.

There has been a great deal of interest in this cytokine since its discovery, because the macrophage, an important target cell of IFN-γ, is a fundamental role player in the immune system.

We argue that, while it is undeniably true that the vast majority of HIV-1 replication occurs in T cells, macrophages may nonetheless represent an important target cell type.

162 Since spermatozoa do not synthesize proteins, the transfer may represent an important target cell-oriented mechanism by which spermatozoa can obtain new proteins and alter their antigenicity or acquire resistance to immune attack and other surface properties.

Our study added more evidence to support that macrophages are important target cells of high salt.

Our findings suggested that macrophages are not only the important target cells but also the effectors during EV71 infection, and they may play an important role in the pathogenesis of EV71 infection.

In addition to DCs, other myeloid cells such as macrophages are also important target cells for HIV-1 and play a role in virus induced immunopathology and progression to AIDS 91.

The humanised VEGF-binding antibody bevacizumab is widely used off-label to treat DME. 5 Although REC are considered the most important target cells of VEGF in the development and progression of this disease, in vitro experiments performed to understand the mechanisms of the therapeutic effects of bevacizumab have been focused almost exclusively on non-retinal EC or RPE cells.

T cells are too small to engulf the previously reported cell lasers and represent an important target for cell tagging due to their complex role in cancer progression and immunotherapy23,27.

Moreover, to demonstrate the immunogenicity of SP cells, we cultured D121 cells with INF- γ (20 ng  μl−1 72 h) and then stained with Hoechest 33342 to collect SP. Expression of MHC-class I antigen on SP cells was detected with H-2Kb or H-2Db antibodies on SP from D121 cells and was found upregulated by incubation with INF- γ, providing an important potential target cell for immunotherapy.

MicroRNAs -192, -215, -194 coordinately regulate important targets in cell cycle regulation such as Smad interacting protein 1, ZEB2, and p53 and may help us better understand the molecular pathways driving the 'intestinalization' of columnar epithelia in BE with a role in BE development.