Sentence examples for important suppression of from inspiring English sources

In a cohort of hyperfiltering (GFR ≥135 mL/min/1.73 m) patients with type 1 DM, we recently demonstrated that NO inhibition with l-NMMA during clamped euglycemia leads to modest declines in GFR and more important suppression of ERPF and cGMP, consistent with dominant preglomerular vasoconstrictive effects observed in animals (13, 32).

Interestingly, we found that not only Rad51 but also Rad52 is important for suppression of hyper-mitotic recombination induced upon loss of FANCM.

Sestrin2-mediated UPR mechanism is important for suppression of obesity-associated NAFLD pathologies including liver damage and steatohepatitis as well as fat accumulation and insulin resistance.

Furthermore, structure-guided substitutions of residues in the KDM2A catalytic pocket abrogate KDM2A-mediated functions important for suppression of cancer cell phenotypes.

PTK6 kinase activity is important for suppression of anoikis of MCF-10A cells, as overexpression of a kinase-inactive MF-PTK6 (KD-MFPTK6) did not significantly rescue these cells from matrix detachment-induced cell death (Figure 3B).

Our results showed that the RRM1 domain has the capacity to interact with the DNA sequence of JCV and that this interaction is important for suppression of viral gene transcription.

Thus, the sufficient K+ concentrations in soybean plant cells should be important for suppression of SMV spread.

Taken together, the results suggest that activation of OXPHOS is more important than suppression of glycolysis in overcoming sorafenib resistance of highly glycolysing HCC cells.

However, maternal treatment had no effect on vaccine efficacy in children 74, implying that infections of children themselves are most important for suppression of vaccine responses.

Conclusions: Our findings demonstrate that GA treatment induces alternations of immunomodulatory gene expression patterns that are important for suppression of disease activity already at three months of treatment and can be used as molecular markers of GA activity.

Thyroid hormones are also demonstrated to increase proliferation of cerebellar granule cells as well as affect apoptosis which is important in suppression of proliferation and downgrading of these cells[ 20, 21].