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These important structural modifications as well as significant changes in bond lengths and angles owing to hydrogen bonding are detailed.
However, more and more examples have surfaced showing that important structural modifications take place while the intermediates are still bound to the assembly line.
Herein, a series of pyrimidine-carbothioamide derivatives 4 a-t) was designed as anticonvulsant agents by doing some important structural modifications in well-known anticonvulsant drugs.
The retrogradation of high amylose starch (5% or 10%), by isothermal cycles at 4 °C (method 1) or by alternating thermal cycles (method 2) was efficient and promoted important structural modifications.
Modeling the nanocubes with our tool NanoTiler and exploring the dynamic characteristics of the models with ANM suggested relatively minor but important structural modifications that enhanced the assembly properties and thermodynamic stabilities.
The other monitored symbols, sCH3 and dsCH, indicate other, less important, structural modifications.
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At annealing temperatures above 600 °C, important structural modification result as deduced from the shift of the XRD peaks towards the low 2θ values indicating changes in the unit cell dimension.
The symbol, aaN, as a important structural modification of the tail part, is indicated in Tables 2 and 4.
The top ES symbol, ssO, represents the most important structural modification, tyrosine moiety, performed on the middle part of PPARγ agonist.
In the interest of realistic representation, it is impossible that an identical important structural modification be represented by two highly positive-correlated descriptors indicating different tendencies.
The rearrangement of the pool of synaptic vesicles from a loose distribution with only a small releasable pool towards a dense organization at the PreAZ is the most important structural modification.
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