The preliminary structure activity relationship studies identified some important structural features considerably influencing the biological effect deserved, providing valuable information for chemists and pharmacologists to design and synthesize more effective antitumor agents bearing the 9,11-secosteroid 9,11-secosteroid
Two important structural features are highlighted by the present uPAR structure.
Thus the large-scale evolutionary integration of sequence-structure-function data, here through reciprocal identification of local, functionally important structural features, may contribute significantly to de-orphaning the structural proteome.
Important structural features and quality requirements are discussed.
The most important structural features and prominent properties of selected LnPOMs are described.
However, structures are available for several other members of this superfamily, and it can be assumed that important structural features are conserved.
When first applied to the well-characterized Dengue Virus (DENV) envelope glycoproteins, coevolution analysis was able to predict important structural features and rearrangements of these viral protein complexes.
Altogether, our work shed light on important structural features of the HCV fusion mechanism and contributes to advance our functional understanding of this process.
In this review, we describe the important structural features of CARs and how this may influence function.
Graphical interpretation of the results revealed important structural features of the inhibitors related to the active site of HDACs.
The structures of many of the pentacyclic triterpenes are known in full detail; that of β-amyrin exemplifies the important structural features of this class of substances.
