This is particularly obvious when both groups have similar p K a values as in protein structures where they play important structural and sometimes catalytic functions (Cleland & Kreevoy, 1994 ▶; Hosur et al., 2013 ▶).
The structure activity analysis of these sulfonamide 4-methoxychalcone derivatives pointed the molecular volume, the HOMO density concentrated in the chalcone moiety and the conformational structure of the compounds as important structural and stereoelectronic features for the antileishmanial activity.
Our results suggest that these typical structures found by the SAR Maps can reveal some important structural and potential functional features for each dataset.
Keratin serves important structural and protective functions, particularly in the epithelium.
Metals are the most commonly encountered protein cofactors, and they play important structural and functional roles in biology.
We present a methodological approach for identification and mapping of important structural and environmental features of forest stands.
However, PDIs from photosynthetic organisms display an important structural and functional diversity considering their association to specific protein domains.
Phospholipid, also called Phosphatide, any member of a large class of fatlike, phosphorus-containing substances that play important structural and metabolic roles in living cells.
"On the microscopic and cell level and tissue level, they really recapitulated some of the critically important structural and mechanical features of the native heart muscle," says Vunjak-Novakovic, was was not involved in the research.
However, by adopting experimental densities appropriate for the corresponding temperatures, some important structural and dynamic features both below and above Tg were revealed using constant-NVT MD simulations.
Enrique Rojas, a former postdoctoral scholar in Huang's lab and first author on the new paper, said that study was a clue that the outer membrane must play important structural and protective roles.
