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However, endometrial hyperplasia induced by unopposed ERT has raised important safety concerns.
The letter said that while the drug, Ranexa, showed evidence of effectiveness, there were "three important safety concerns" that had to be addressed with more studies before the drug could be approved.
These applications could have raised important safety concerns or included poorly designed trials that could not support approval.
Important safety concerns need to be addressed before HSC-based immunotherapy can be applied to clinical practice.
The use of viral gene transfer in Treg therapy settings confers the ability to address several important safety concerns.
There were important safety concerns with ustekinumab.
Similar(43)
Graphite dust is an important safety concern of high-temperature gas-cooled reactor (HTR).
An important safety concern in the design of plasma facing components is the retention of hydrogen isotopes.
The issue of spontaneous ignition of highly pressurized hydrogen release is of important safety concern, e.g. in the assessment of risk and design of safety measures.
Excursion of catalyst surface temperature is an important safety concern in deployment of a passive catalytic recombiner device in the nuclear reactor containment.
In this regard, the response of fuel pins under off-normal events is an important safety concern, being the understanding and modelling of cladding performance a relevant issue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com