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This set of compounds confirm that the lipophilic nature of the cyclohexyl substituent is important; replacement of the heteroatom with a carbon atom gives a minimal 10-fold increase in activity (compare compounds 38 and 39 with 43, and 40 with 25).
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One of the most important replacement methods used instead of chemical herbicide and conventional tillage is cover and companion crops' application which is a major factor in sustainable agriculture.
In 1959 Russell and Burch stated that "Mammalian tissue cultures have become one of the most important replacement techniques".
Serotype 19A is of considerable concern as an important replacement serotype in carriage and invasive disease.
Design of corneal endothelium substitute is important for replacement of cadaveric cornea tissue.
Also important was the replacement of the traditional distaff for spinning wool with the spinning wheel, which tripled production over hand spinning.
The preclinical evidence for a graft-vs-autoimmune effect important in the replacement of a dysfunctional immune system by allogeneic HSCT has been subsequently supported by clinical evidence.
Furthermore, it has been suggested that this facilitates enhanced protein turnover which is important in the replacement of damaged proteins and proteins involved in metal detoxification, repair and storage.
Due to their ease of operation and greater efficiency, nanofibrous membranes will play an important role in the replacement of conventional membranes in the near future [5].
Today, we are witnessing the first wave of a similarly important technological advance: the replacement of conventional photomultiplier tubes with solid-state photomultipliers, which holds great promise to reduce the size and increase the performance of PET scanners [9, 10].
The rules were based largely on the Rugby Football Union's code from England, though one important difference was the replacement of a kicked goal with a touchdown as the primary means of scoring (a change that would later occur in rugby itself, favoring the try as the main scoring event).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com