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This may be an important reason underlying the varying patterns of risk factors found across different countries/regions [ 16].
Another important reason underlying the need of such distinction is that a disease may originate with two subsequent mutations according to the two-hit hypothesis [ 42].
In conclusion, these data show that an important reason underlying elevated oxidative stress in type 2 diabetes is deficiency of glutathione, which occurs because of the decreased synthesis caused by limited availability of the precursor amino acids cysteine and glycine.
Furthermore, since NPC includes a spectrum of squamous, and keratinising versus non-keratinising subtypes which are linked to differential risk factors, this may also be an important reason underlying the varying patterns of ecological associations found across different jurisdictions.
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It was also reported that the propaganda of the media is among the important reasons underlying the failure of the vaccination campaign [ 15].
The physiological reason underlying this claim is not well understood.
The reason underlying such discrepancy is unclear.
The reason underlying this difference is unknown.
The reason underlying these background differences is unclear to us.
One may wonder the reason underlying this phenomenology.
The reason underlying this observation is yet to be elucidated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com