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Our results suggest that repertoire analysis of antigen-specific TCRs can be an important readout to assess whether a vaccination was able to generate memory cells in clonal sizes that are necessary for immune protection.
TFE3 post-translational modifications and its subcellular localization could be an important readout for the analysis of FLCN function and the function of the FLCN/FNIP1/FNIP2/AMPK complex.
The importance of TRAIL suggests that TRAIL production by T cells or NK cells could be an important readout to predict the efficacy of cancer vaccines or immunotherapies, possibly equally important as perforin-mediated cell apoptosis and IFN-γ.
Hence, in our model, the observed cerebellar abnormalities are another important readout to monitor the effectiveness of the therapeutic protocols.
In most of these approaches, levels of epigenetic signals are linked to a biologically important readout (e.g. transcript level [ 21, 22] or polymerase occupancy [ 20]).
Since mRNA expression is an important readout of underlying genetic and epigenetic signatures, we attempted to identify which leukocyte population might be a relevant cell target for ORMDL3.
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Imaging glucose, its derivatives and the activation of β-cells in vivo is another important functional readout of the pancreas.
Infarct size is a particularly important scientific readout as virtually all cardiocirculatory pathways are affected by it.
Response to neoadjuvant treatment is an important clinical readout for tumour biology and was first described by Lowy et al. for gastric adenocarcinomas (Lowy et al, 1999).
Liver function may reflect an important acute readout of nutraceutical benefit in otherwise healthy individuals, as this organ is responsive to acute environmental changes (e.g., [ 93, 94]), ranging from dietary/pharmaceutical input to pathological states.
This paper summarizes a few designs aspects particularly important for pixel readout chips.
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