An important problem of a single outcome indicator is that, while services might improve dramatically, this does not always produce a change in the main outcome indicator in the time one can allow between measurement cycles.
Every three or four months, we select a region with important problems of attendance and provide a special bus to take them to the PABHC.
This work by Hladik addresses one of the most important problems of HIV research: the persistence of a "latent reservoir" in spite of the virtually complete suppression of viral replication.
Reviewer 1: Mikhail Gelfand, Department of Bioengineering and Bioinformatics, Moscow State University, and Institute for Information Transmission Problems RAS, Moscow, Russia The paper addresses an important problem of selecting a good similarity measure for comparing gene expression patterns.
Motivation:Despite recent advances of modern GWAS methods, it is still remains an important problem of addressing calculation an effect size and corresponding p-value for the whole gene rather than for single variant.
For the clinically important problem of determining whether a given primary tumor will metastasize, tree level features show improved prediction accuracy by at least 3.5% over all other feature sets considered, including comparable feature sets from the earlier unweighted models.
"It puts a quantitative spin on that feeling that we're solving really important problems for a big chunk of the world," not just Silicon Valley, Houston tells me.
This paper addresses an important problem of integrating structural optimization into a traditional CAx system and therefore, realizes an integrated product design-optimization system.
Level set methods are versatile and extensible techniques for general front tracking problems, including the practically important problem of predicting the advance of a fire front across expanses of surface vegetation.
This solution is generalized, using Happel's free-surface model, to cover the practically important problem of flow relative to a swarm of permeable spheres.
