Owing to the high polarity and hydrophilia of EC, an important problem still remains because the adsorption by sample matrix causes low transport of EC to the headspace and thus invalidates MHS-SPME for quantification.
However, an important problem still remains to be resolved: the incorrect use of the different inhaler devices, even in compliant patients, in whom it should also be evaluated.
However, the most important problem still remains; after the systemic intravenous administration of Ad/5HREp-BCD, we did not detect the expression of BCD in the tumour xenografts in the immunohistochemical analysis (data not shown).
In addition to these methodological concerns, an important problem also remains about the way our study (or for that matter any study in this domain) deals with the classification of unobserved days due to coma or sedation.
After the first Surgeon General's report on smoking and health in 1964, the prevalence of cigarette smoking in the United States began a gradual decline [ Department of Health and Human Services (DHHS) 2000a], although the use of tobacco continues to be an important problem and remains the leading preventable cause of death and disability in the United States (DHHS 2004).
An important open problem remains to determine the dynamic uninformed fingerprinting capacity, which may prove or disprove that the construction of [40] combined with the universal decoder g of Section 3 is asymptotically optimal.
Mr Bush is left looking terribly lame despised by Democrats and overwhelmingly opposed by his own party on his last gamble at a piece of big legislation.Most important, the immigration problem remains unsolved.
Illicit anabolic-androgenic steroid (AAS) abuse, though an important public health problem, remains inadequately studied.
Mechanisms to deploy and retain midwives in rural areas are being tested but the problem remains important and complex [ 12].
"So it's important that awareness about the problem remains high, but to be honest, I have my doubts that it will".
