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The important points addressed in each section of the manuscript to help gene annotators to address specific issues that they may encounter are highlighted in Figure 1.
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In addition, an important point addressed by our acute asthma model in this study is the phagocytosis of nanoparticles during a lung inflammatory response.
The reviewer has raised a very important point about addressing the reason for aberrant miRNA expression in MM.
Indeed, we agree that the timing of these patterning processes is important point to address, and so we have added new gene expression data to clarify the time point at which the proximal skeletal elements begin to be patterned.
An important point to address with respect to DFMO-induced polyamine depletion is that it has been shown to decrease intracellular concentrations of calcium resulting in increased membrane permeability in the normal intestinal cell line IE-6 [ 23].
We have not added this point to the text as it would take a couple of paragraphs (and many citations) to flesh out this idea in a cogent manner, but we would be happy to do so if you think that it's an important point to address.
There are two important points to be addressed: 1) The quality of the image of an 8-shaped mitoplast on Figure 1A is rather low.
Overall, I believe that, although the study has produced some interesting observations, and the authors' approach seems promising, the manuscript in the present form is rather raw and badly structured (it really looks like several independent papers half-written and stitched together), and several important points are not addressed at all.
The most important points to address are listed below.
In order to develop rational design procedures for stirred vessels, several important points have to be addressed.
Although previous reports using cats showed that eye-specific projection patterns of RGC axons in the LGN could further be altered by monocular enucleation (ME) even after eye-specific segregation has occurred [16] [18], several important points have not been addressed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com