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Lewy body pathology [ 36] is an important pathological feature of Parkinson's disease observed in most genetic forms, and in several idiopathic cases [ 39].
Interestingly, the common denominator in most of these situations with α-synuclein accumulation appears to be lysosomal dysfunction: Lewy body pathology [ 36 ] is an important pathological feature of Parkinson's disease observed in most genetic forms, and in several idiopathic cases [ 39 ].
In addition to grey matter pathology, white matter changes are now recognized as an important pathological feature in the emergence of the disease.
Accumulating evidence shows that retinal neuron degeneration is an important pathological feature contributing to vision impairment in diabetic retinopathy [14].
The oxidative damage of Müller cells and retinal neuronal cells has been shown to be an important pathological feature in some ocular diseases, such as diabetic retinopathy or light-induced retinopathy [18], [28], [29].
Another important pathological feature is fibrosis [ 4, 16– 18, 31, 32].
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As important pathological features may be hidden, special care should be taken to obtain good distension of the transverse colon in the prone position.
These findings share similarities with important pathological features found in AMD and suggest the relevance of microglia-RPE interactions in AMD pathogenesis.
In a parallel fashion, in concert with genetic events (mutation, deletion and gene amplification) it is thought that epigenetic alterations may precipitate important pathological features of malignant degeneration [4].
These were two important pathological features of gastric cancer.
Lauren-classification and human epidermal growth factor receptor 2 (HER2) status are two important pathological features of gastric cancer patients.
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